Main Street Pharmacy offers a wide array of prescription services designed to meet the diverse needs of our community. Beyond the convenience of online refills and transfers, we provide personalized medication therapy management, where our pharmacists work closely with you to ensure your medication regimen is optimized for your health conditions. Our compounding service allows for customized medication strengths and forms, catering to specific patient needs, including allergies or difficulty swallowing pills. We also offer medication synchronization, aligning your prescription refills to a single day each month, simplifying your medication management and improving adherence. For those with complex treatment schedules, our pharmacists are available for consultations, offering expert advice on medication interactions and side effects. At Main Street Pharmacy, we’re committed to providing comprehensive, compassionate care to help you manage your health effectively.

As a full-service pharmacy, we're equipped to meet all your health needs. From prescription refills, medication therapy management, and compounding to travel vaccinations, COVID-19 testing, and weight management services, we've got you covered. Our dedicated team is here to provide personalized care, ensuring you receive the best treatment possible. Whether it's managing your medications or preparing for a trip abroad, we're ready to assist with any health concern. Trust us to be your partner in wellness.

At our pharmacy, we specialize in compounding, a service that lets us tailor medications to your specific needs. Whether it's for dermatology, your pets, or unique formulations like numbing creams, hormone replacement therapy (HRT) in various forms, low dose Naltrexone, pain relief creams, or solutions for erectile dysfunction, we've got you covered. Our compounding options ensure that you receive your medication in the form that works best for you, providing personalized care that meets your individual health requirements.

Our pharmacy is committed to meeting our community's COVID-19 testing needs, offering fast and easy solutions for all variants. We provide OTC at-home tests, in-pharmacy Antigen and PCR testing conducted by our trained staff, with the option of receiving a results paper. Contact us today to find out more about our comprehensive testing services and how we can assist you.

Heading to Africa, Central America, or South America? Ensure you're vaccinated before you travel. Our pharmacy offers essential travel immunizations to protect against diseases like malaria, yellow fever, and typhoid, keeping you safe on your journey. Not sure what you need? We're here to help. For full protection, get vaccinated 4-6 weeks before your trip. Talk to us today about your travel vaccination needs and enjoy your travels without health worries.

Our Medication Therapy Management (MTM) program helps you manage medications and health conditions effectively. Struggling with multiple medications, side effects, or questions about your prescriptions? MTM is for you. Our pharmacists offer personalized support, ensuring you're up-to-date with vaccines, understand your medication regimen, and can manage costs. Benefit from tailored advice on diet and exercise too. Schedule an MTM session today for a healthier life.

Our pharmacy is committed to meeting our community's COVID-19 testing needs, offering fast and easy solutions for all variants. We provide OTC at-home tests, in-pharmacy Antigen and PCR testing conducted by our trained staff, with the option of receiving a results paper. Contact us today to find out more about our comprehensive testing services and how we can assist you.

Our pharmacy proudly offers a wide selection of top-quality supplements from trusted brands like Pure Encapsulations, Designs for Health, XYMOGEN, Orthomolecular, and Metagenics. These brands are known for their high standards and commitment to purity and effectiveness. Whether you need vitamins, minerals, herbal supplements, or specialized nutritional support, we've curated the best products to support your health journey. Your well-being is our priority, and we're dedicated to providing the finest supplements to help you reach your health goals.
*Delivery is available within a 5 mile radius of Main Street Pharmacy
Rachel Broadwater2025-09-17Trustindex verifies that the original source of the review is Google. I love supporting this locally owned pharmacy in the heart of downtown Safety Harbor! Phyllis is not only knowledgeable but also truly cares about her patients. If you want to use a pharmacy where you are more than just another patient, go to Main Street Pharmacy and you will immediately see the difference ❤️ T Mac2025-09-16Trustindex verifies that the original source of the review is Google. Wonderful small owned pharmacy that cares ❣️ Eva Mavrakos2025-09-05Trustindex verifies that the original source of the review is Google. Local Safety Harbor staple!!!!! Miss Chaffee2025-06-23Trustindex verifies that the original source of the review is Google. I have been using their Weight Management services here for over 6 months now, AND I have successfully lost 35 pounds!! I have recently transitioned into their maintenance phase to keep the weight off. I can honestly say, their team really cares and has the systems in place to make you successful. Their prices are more economic than most places around and you actually work with a trained Nurse Practitioner at each session; Ms. Jordan has been a delight to work with throughout this entire process! I absolutely love their staff; it's a wonderful locally owned business. I highly recommend them! Scott Chaffee2025-06-23Trustindex verifies that the original source of the review is Google. Main Street Pharmacy is great! The staff is always very pleasant and helpful. It is also nice to support a small, local business. In their weight management department, Jordan is always very nice and takes time to explain and answer any questions you may have. I cannot recommend this establishment enough for all your needs. Debra Balkman2025-05-30Trustindex verifies that the original source of the review is Google. Personal service... James2025-04-22Trustindex verifies that the original source of the review is Google. I can’t believe it’s taken me this long to write a review, but I’ve been coming here since 2019—and I truly can’t say enough good things. Phyllis and the entire team are absolutely incredible. They’re always so helpful, knowledgeable, and genuinely caring. It’s such a comforting feeling to walk in and be greeted by name, and even more special to see the same familiar faces year after year. That kind of consistency and warmth is rare, and it means so much. Thank you all for everything you do! - James